Protein Details: Transient receptor potential cation channel subfamily M member 5

Protein ID

ICDB_Pro_1532

Protein Name

Transient receptor potential cation channel subfamily M member 5

Gene Name

Trpm5; Ltrpc5; Mtr1

Organism

Mus musculus (Mouse)

Length

1158 amino acids

AlphaFoldDB

AF-Q9JJH7-F1-model_v4.pdb

Function

Sequence

MQTTQSSCPGSPPDTEDGWEPILCRGEINFGGSGKKRGKFVKVPSSVAPSVLFELLLTEWHLPAPNLVVSLVGEERPLAMKSWLRDVLRKGLVKAAQSTGAWILTSALHVGLARHVGQAVRDHSLASTSTKIRVVAIGMASLDRILHRQLLDGVHQKEDTPIHYPADEGNIQGPLCPLDSNLSHFILVESGALGSGNDGLTELQLSLEKHISQQRTGYGGTSCIQIPVLCLLVNGDPNTLERISRAVEQAAPWLILAGSGGIADVLAALVSQPHLLVPQVAEKQFREKFPSECFSWEAIVHWTELLQNIAAHPHLLTVYDFEQEGSEDLDTVILKALVKACKSHSQEAQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMTDALVSNKPDFVRLFVDSGADMAEFLTYGRLQQLYHSVSPKSLLFELLQRKHEEGRLTLAGLGAQQARELPIGLPAFSLHEVSRVLKDFLHDACRGFYQDGRRMEERGPPKRPAGQKWLPDLSRKSEDPWRDLFLWAVLQNRYEMATYFWAMGREGVAAALAACKIIKEMSHLEKEAEVARTMREAKYEQLALDLFSECYGNSEDRAFALLVRRNHSWSRTTCLHLATEADAKAFFAHDGVQAFLTKIWWGDMATGTPILRLLGAFTCPALIYTNLISFSEDAPQRMDLEDLQEPDSLDMEKSFLCSRGGQLEKLTEAPRAPGDLGPQAAFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGSEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVEDNWNKCDMVAIFLFIVGVTCRMVPSVFEAGRTVLAIDFMVFTLRLIHIFAIHKQLGPKIIIVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSLHPLLLESSASCPNLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYHLIVEYHGRPALAPPFILLSHLSLVLKQVFRKEAQHKRQHLERDLPDPLDQKIITWETVQKENFLSTMEKRRRDSEGEVLRKTAHRVDLIAKYIGGLREQEKRIKCLESQANYCMLLLSSMTDTLAPGGTYSSSQNCGCRSQPASARDREYLESGLPPSDT

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Strongly expressed in liver; heart; testis; brain and kidney. Detected in fetal liver; kidney; spleen; brain; heart and lung; and in adult skin; eyes; spleen; stomach; small intestine; colon; lung; bladder; pancreas and thymus. Biallelically expressed at all stages and tissues examined. Biallelically expressed at all stages and tissues examined. Biallelically expressed at all stages and tissues examined. Also expressed in subsets of taste receptor cells of the tongue; in olfactory sensory neurons of the main olfactory epithelium and in the vomeronasal organ. .

DOI ID

10.1093/dnares/7.3.195; 10.1006/geno.2000.6234; 10.1093/hmg/9.12.1829; 10.1016/s0960-9822(03)00431-7; 10.1101/gr.2596504; 10.1126/science.1112014; 10.1038/nn952; 10.1073/pnas.2334159100; 10.1016/j.ceca.2004.11.001; 10.1074/jbc.m414072200; 10.1038/nature04248; 10.1016/j.bbalip.2006.07.005; 10.1093/chemse/bjj027; 10.1186/1471-2202-8-49; 10.1523/jneurosci.4973-06.2007; 10.1073/pnas.0610201104

RefSeq

NP_064673.2 [Q9JJH7-1]; XP_006508708.1 [Q9JJH7-1]; XP_006508709.1 [Q9JJH7-3]